XWikiGen: Cross-lingual Summarization for Encyclopedic Text Generation in Low Resource Languages

Lack of encyclopedic text contributors, especially on Wikipedia, makes automated text generation for low resource (LR) languages a critical problem. Existing work on Wikipedia text generation has focused on English only where English reference articles are summarized to generate English Wikipedia pages. But, for low-resource languages, the scarcity of reference articles makes monolingual summarization ineffective in solving this problem. Hence, in this work, we propose XWikiGen, which is the task of cross-lingual multi-document summarization of text from multiple reference articles, written in various languages, to generate Wikipedia-style text. Accordingly, we contribute a benchmark dataset, XWikiRef, spanning ~69K Wikipedia articles covering five domains and eight languages. We harness this dataset to train a two-stage system where the input is a set of citations and a section title and the output is a section-specific LR summary. The proposed system is based on a novel idea of neural unsupervised extractive summarization to coarsely identify salient information followed by a neural abstractive model to generate the section-specific text. Extensive experiments show that multi-domain training is better than the multi-lingual setup on average

In silico study of RxLR effectors of Phytophthora infestans HP-10-31, A2 mating type potato late blight pathogen

Phytophthora infestans is one of the most compelling plant pathogen among the scientific community throughout the world. It is the causative agent of potato late blight and responsible for tremendous economic loss worldwide. Pathogenic effector proteins are instrumental in modulating host immunity and disease resistance has been a major concern. In P. infestans, a class of cytoplasmic effectors recognized as RxLR is characterized by highly conserved region and abet in parasitic colonization by modifying the host defense system. We have sequenced an Indian strain of P. infestans HP-10-31 genome and identified several RxLR motif-containing genes.In this study we selected two RxLR effector genes named contig15921_2 and contig06738_6 from this A2 mating type strain. We used I-TASSER server to generate three-dimensional structure and observe the Nicotinamide adenine dinucleotide and S-adenosyl-Lhomocysteine conserve domains. Our in silico study reveals the binding properties of these proteins are favorable with corresponding ligands. This study gives insight into the interaction between putative RxLR effector proteins with its ligand that further aid our understanding of host-pathogen interaction and help in designing new agents to combat the agro pathogenicity

Comparison of concomitant boost radiotherapy against concurrent chemoradiation in locally advanced oropharyngeal cancers: A phase III randomised trial

AbstractPurposeTo test the toxicity and efficacy of concomitant boost radiotherapy alone against concurrent chemoradiation (conventional fractionation) in locally advanced oropharyngeal cancer in our patient population.Methods and materialsIn this open-label, randomised trial, 216 patients with histologically proven Stage III–IVA oropharyngeal cancer were randomly assigned between June 2006 and December 2010 to receive either chemoradiation (CRT) to a dose of 66Gy in 33 fractions over 6.5weeks with concurrent cisplatin (100mg/m2 on days 1, 22 and 43) or accelerated radiotherapy with concomitant boost (CBRT) to a dose of 67.5Gy in 40 fractions over 5weeks. The compliance, toxicity and quality of life were investigated. Disease-free survival (DFS) and overall survival (OS) curves were estimated with the Kaplan–Meier method and compared using log rank test.ResultsThe compliance to radiotherapy was superior in concomitant boost with lesser treatment interruptions (p=0.004). Expected acute toxicities were significantly higher in CRT, except for grade 3/4 mucositis which was seen more in CBRT arm (39% and 55% in CRT and CBRT, respectively; p=0.02). Late toxicities like Grade 3 xerostomia were significantly high in CRT arm than CBRT arm (33% versus 18%; p<0.0001). The quality of life was significantly poor in CRT arm at all follow up visits (p<0.0001). The rates of 2year disease-free survival were similar with 56% in the chemoradiotherapy group and 61% in CBRT group (p=0.2; HR-0.81, 95%CI-0.53–1.2). Subgroup analysis revealed that patients with nodal size >2cm had significantly better DFS with CRT (p=0.05; HR-1.59, 95%CI-0.93–2.7).ConclusionIn selected patients of locally advanced oropharyngeal cancer, concomitant boost offers a better compliance, toxicity profile and quality of life with similar disease control, than chemoradiation

Enablers to implement sustainable initiatives in agri-food supply chains

yesDue to rapid agricultural industrialization, increased global food demand, and, increasing concerns related to food quality and safety, the concepts of sustainability and supply chain transparency are becoming critically important to the agriculture and agri-food sector. The new focus on sustainability performance objectives emphasizes the effective utilization and consumption of natural resources to balance ecological, economic and societal aspects of agri-food businesses. The management of sustainability adds a new demand on business managers who often have small profits and receive stringent requirements from large powerful customers and retailers. In this paper, we recognize and analyze the key enablers in implementing sustainable initiatives for Agri-Food Supply Chains (A-FSCs). Ten important sustainability driven enablers were considered from a rigorous literature review and phase of expert consultation. The identified enablers were then analyzed using a combined Interpretive Structural Modeling (ISM) - fuzzy Decision Making Trial and Evaluation Laboratory (DEMATEL) based framework. The ISM approach enabled an appreciation of the contextual relationships among the enablers and to classify the enablers based on their driving and dependence potential. The fuzzy DEMATEL technique supported the determination of the influential and influenced enablers and also to categorize them into cause and effect groups. An empirical case study, drawn from a vegetable and fruit retail supply chain in India, is used to focus and test the applicability of the proposed research framework. The paper facilitates professional management practice and researchers to uncover and explore the enablers for the real execution of sustainability oriented initiatives in the agri-food business sector

Intraarticular distal end radius fractures treated with volar locking plate variations

Introduction: “Distal end radius fractures” account for almost 16% of all fractures and are the most common kind of upper limb fractures treated in hospital emergency departments. “Distal end radial fractures” occur more often in younger people due to high-energy trauma than in older people due to low-energy trauma. When comparing women and men of the same age, proximal end radii fracture are more prevalent in women than men owing to significant osteoporosis and a higher tendency for accidents in older women. Methodology: This was a prospective interventional study in which participants were divided in to two groups. Result and Conclusion: Both groups in the study had comparable range of motion, with the exception of the forearm”, where the “variable angle volar locking plate” excelled. The risk of complications was low in both approaches. Thus we conclude that when it comes to treating “displaced intra-articular distal end radius” fractures, the variable angle volar locking plate is superior than the Ellis locking plate

Revisiting the therapeutic potential of homeopathic medicine Rhus Tox for herpes simplex virus and inflammatory conditions

Background: Herpes simplex virus type-1 and type-2 cause a viral disease named Herpes. Genital herpes is mainly caused by HSV-2 with symptoms of painful and itchy blisters on the vagina, cervix, buttocks, anus, penis, or inner thighs with blisters that rupture and convert into sores. The homeopathic remedy Rhus Tox has been widely used to treat herpes and has shown in vitro anti-inflammatory effects in previous studies. Purpose: The presented review focuses on relapses and harmful effects caused by acyclovir in modern medicine and the probable antiherpetic activity of Rhus Tox on HSV infection based on its pathophysiology, preclinical findings, on primary cultured mouse chondrocytes, mouse cell line MC3T3e1 and a comparative study of Natrum Mur with Rhus Tox on HSV infection. Study design: The design of the study focuses mainly on the descriptive data available in various literature articles. Method: Databases such as PubMed, Google Scholar, Medline and ScienceDirect were used to search the articles. Articles are selected from 1994 to 2022 focusing solely on the competence of Rhus Tox against herpes. Keywords used for the study are antiviral, Herpes, Rhus Tox, in vitro and homeopathy. Results: The review includes fifteen articles, including 4 full-text articles on HSV, 6 in vitro studies of homeopathic compounds performed on the herpes virus, and 5 articles based on the pathophysiology and effects of Rhus tox. The review article proposes the anti-inflammatory and antiviral action of the homeopathic remedy Rhus Tox which can be used in crisis conditions when the physician doubts the simillimum, as it prevents further outbreaks of HSV infection. Conclusion: The homeopathic medicine Rhus Tox has no cytotoxicity observed under in vitro conditions and can be used to treat herpes infection. Further studies are needed to confirm the results under in vitro and in vivo conditions as well as in clinical trials

Prevalence of calcified carotid artery atheromas on panoramic radiographs of renal stone patients

The aim of the present study was to evaluate the prevalence of calcified carotid artery atheromas detected on panoramic radiographs of patients with renal stones and to assess the correlation of renal stones and carotid artery calcifications (CAC). Panoramic radiographs of 120 renal stone patients (76 males and 44 females) and 120 controls (68 males and 52 females) were examined for any calcifications in the carotid artery. The mean age of the patients with renal stones and controls was 40.6 ± 7.8 years and 41.1 ± 6.7 years, respectively. A total of 25 (20.8%) patients with renal stones and 16 (12.3%) patients from the control group showed CAC. The calcifications were however higher in the patients with renal stones, but there was no statistically significant difference (P >0.05) between the two groups. CAC was found in 15 males and ten females with renal stones and nine males and seven females of the control group, and this difference was not statistically significant (P >0.05). In the present study, no significant relationship was found between the presence of CAC in the patients with renal stones and the control group. However, there was a trend for higher prevalence of CAC in renal stone patients

Comparative evaluation of efficacy of different endodontic file systems for removal of gutta percha from root canals using CBCT: An in-vitro study

Aim- To evaluate the removal of gutta percha by hand file system, rotary file system and reciprocating file system from root canals by using CBCT. Materials and Method: Root canals of 42 extracted human mandibular premolars were prepared using the ProTaper Universal rotary system and then obturated. Root filling quality was confirmed on CBCT images. Specimens were divided into 3 groups (n = 14) according to the system used for filling removal, group 1: H File, group 2: MTwo rotary retreatment file, and group 3: WaveOne file. Each specimen was sent for CBCT Analysis. Statistical Analysis Used: Evaluation of data was done statistically using One-way Analysis of Variance and Tukey’s post hoc test. Results: There was statistical difference in all the groups (P&gt;0.05). All systems demonstrated presence of remnants of filling material. Mean reduction in the volume of GP after retreatment of Group I was 0.006mm3, Group II was 0.002mm3 Group III was 0.003mm3. Conclusion: The system responsible for a better removal of root canal filling material was the MTwo Retreatment file system, followed by the WaveOne system and H File

Comparative evaluation of efficacy of different endodontic file systems for removal of gutta percha from root canals using CBCT: An in-vitro study

Aim- To evaluate the removal of gutta percha by hand file system, rotary file system and reciprocating file system from root canals by using CBCT. Materials and Method: Root canals of 42 extracted human mandibular premolars&nbsp; were prepared using the ProTaper Universal rotary system and then obturated. Root filling quality was confirmed on CBCT images. Specimens were divided into 3 groups (n = 14) according to the system used for filling removal, group 1: H File, group 2: MTwo rotary retreatment file, and group 3:WaveOne file. Each specimen was sent for CBCT Analysis. Statistical Analysis Used: Evaluation of data was done statistically using One-way Analysis of Variance and Tukey’s post hoc test. Results: There was statistical difference in all the groups (P&gt;0.05). All systems demonstrated presence of remnants of filling material. Mean reduction in the volume of GP after retreatment of Group I was 0.006mm3, Group II was 0.002mm3 Group III was 0.003mm3. Conclusion: The system responsible for a better removal of root canal filling material was the MTwo Retreatment file system, followed by the WaveOne system and H File